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Coriell Institute for Medical Research
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Image Search Results
Journal: Journal of Radiation Research
Article Title: Low-dose energetic protons induce adaptive and bystander effects that protect human cells against DNA damage caused by a subsequent exposure to energetic iron ions
doi: 10.1093/jrr/rrv005
Figure Lengend Snippet: Proton-induced adaptive response in normal human cells. ( A ) Experiment schematic: Confluent normal human fibroblast cultures were first exposed to a priming radiation dose from energetic low-LET protons, followed 0, 6 or 24 h later by a challenge dose of high-LET iron ions. ( B ) Micronucleus formation (left panel) and micronuclei distribution (right panel) in AG1522 cells pre-irradiated with 20 cGy from 1-GeV protons ( 1 H) and challenged 0, 6 or 24 h later with 50 cGy of 1-GeV/u iron ions ( 56 Fe). ( C ) Micronucleus formation (left panel) and micronuclei distribution (right panel) in AG1522 cells pre-irradiated with 20 cGy from 0.05-GeV protons ( 1 H) and challenged 0, 6 or 24 h later with 50 cGy of 1-GeV/u iron ions ( 56 Fe). The data indicate that pre-exposure to a low dose of low-LET protons protects against DNA damage from a subsequent challenge from high-LET iron ions. * P < 0.05, ** P < 0.0001.
Article Snippet: Apparently
Techniques: Irradiation